VENTRICULAR FIBRILLATION IN THE ISOLATED RABBIT HEART
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چکیده
منابع مشابه
Modulation of extracellular atrioventricular node field potential pattern and ventricular rhythm by morphine in experimental atrial fibrillation in isolated rabbit heart
Introduction: Endorphins are produced by cardiomyocytes, and exert different effects on the heart. The aim of the present study is to assess morphine effects on extracellular atrioventricular (AV) node field potential pattern and ventricular rhythm of isolated rabbit heart during experimental atrial fibrillation (AF). Methods: Effects of different concentrations of morphine (10, 20, 50 and 1...
متن کاملThe initiation of ventricular tachycardia and fibrillation by procaine in the isolated-perfused rabbit heart.
An accelerating ventricular tachycardia ending in fibrillation can be initiated in isolated hearts by procaine injections after the administration of epinephrine, but not in untreated hearts. The run of tachycardia consists of a supraventricular or idioventricular impulse followed by an accelerating train of premature systoles coupled to it. Fibrillation results when the train reaches a frequen...
متن کاملThe Initiation of Ventricular Tachycardia and Fibrillation by Procaine in the Isolated- Perfused Rabbit Heart
An accelerating ventricular tachycardia ending in fibrillation can be initiated in isolated hearts by procaine injections after the administration of epinephrine, but not in untreated hearts. The run of tachycardia consists of a supraventricular or idioventricular impulse followed by an accelerating train of premature systoles coupled to it. Fibrillation results when the train reaches a frequen...
متن کاملEffects of tedisamil (KC-8857) on cardiac electrophysiology and ventricular fibrillation in the rabbit isolated heart.
1. The direct cardiac electrophysiological and antifibrillatory actions of tedisamil (KC-8857) were studied in rabbit isolated hearts. 2. Tedisamil (1, 3, and 10 microM), prolonged the ventricular effective refractory period (VRP) from 120 +/- 18 ms (baseline) to 155 +/- 19, 171 +/- 20, and 205 +/- 14 ms, respectively. Three groups of isolated hearts (n = 6 each) were used to test the antifibri...
متن کاملQuantification of effects of global ischemia on dynamics of ventricular fibrillation in isolated rabbit heart.
BACKGROUND Ventricular fibrillation (VF) leads to global ischemia of the heart. After 1 to 2 minutes of onset, the VF rate decreases and appears more organized. The objectives of this study were to determine the effects of no-flow global ischemia on nonlinear wave dynamics and establish the mechanism of ischemia-induced slowing of the VF rate. METHODS AND RESULTS Activation patterns of VF in ...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology and Chemotherapy
سال: 1957
ISSN: 0366-0826
DOI: 10.1111/j.1476-5381.1957.tb00122.x